AMSN Seminar - Dr Alyson Fournier
Tue, Feb 27
|University of Alberta
"Molecular strategies to promote neuroprotection in response to pathological inflammation" Note: This event is for researchers, clinicians and trainees
Time & Location
Feb 27, 2024, 12:00 p.m. – 1:00 p.m. MST
University of Alberta, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada
About The Event
JOIN US FEB 27 at 12PM (MT)!
In person in Edmonton (Room TBD)
or via Zoom
Talk Synopsis:
In multiple sclerosis (MS), invasion of the central nervous system by peripheral immune cells, activation of resident microglia and astrocytes, and demyelination occur as a cascade of events that trigger neuronal damage and death. Analysis of molecular signals in neurons that activate damage in response to the complex immune environment is important for development of novel strategies to promote neuroprotection. Profiling of neurons isolated from animals subjected to Experimental Autoimmune Encephalomyelitis and of neurons from patients with Multiple Sclerosis have revealed a molecular signature reminiscent of aged neurons with features of senescence and upregulation of classic inflammatory genes. Strategies to rejuvenate neurons and to neutralize signalling from pro-inflammatory molecules exhibit neuroprotective activity raising promising avenues for future development of therapeutic agents.